Michael-John Dolan

Bio

I am a Life Sciences Research Foundation Postdoctoral Fellow at the Broad Institute of MIT and Harvard and Harvard Medical School, in the labs of Prof. Beth Stevens and Dr. Evan Macosko. My research focuses on building and applying novel molecular, viral, genomic and bioinformatic tools to understand microglia, the resident immune cells of the brain. I am particularly interested in how these cells coordinate brain plasticity and repair, with a current focus on remyelination.

Education

University of Cambridge, UK | 2017

Doctor of Philosophy in Neuroscience | Supervisor: Dr. Gregory Jefferis

Maynooth University, Ireland | 2011

Bachelor of Science in Biology and Applied Mathematics

Experience

Broad Institute of MIT and Harvard, USA | August 2018 - Present

Postdoctoral Fellow | Supervisors: Prof. Beth Stevens and Dr. Evan Macosko

Janelia Research Campus, USA | March 2017 - August 2018

Postdoctoral Fellow | Supervisors: Drs. Gerald Rubin and Gregory Jefferis

Selected Publications

A full bibliography can be found here. | ’*’ denotes joint first authorship.

Goeva A, Dolan M-J, Luu J, Garcia E, Boiarsky R, Gupta RM, Macosko E (2023) HiDDEN: A machine learning label refinement method for detection of disease-relevant populations in case-control single-cell transcriptomics Biorxiv (Submitted) https://doi.org/10.1101/2023.01.06.523013 | Link

Dolan M-J*, Therrien T*, Jereb S, Kamath T, Atkeson T, Marsh S, Goeva A, Lojek N, Murphy S, Joung J, Liu B, Limone F, Eggan K, Hacohen N, Bernstein B, Glass C, Leinonen V, Blurton-Jones M, Zhang F, Epstein C, Macosko E, Stevens B. (2022) A resource for generating and manipulating human microglial states in vitro Biorxiv (Accepted at Nature Immunology) https://doi.org/10.1101/2022.05.02.490100 | Link

^Article featured in Alzforum, an information nexus for neurodegeneration research | Link

Dolan M-J, Frechter S, Bates AS, Dan C, Huoviala P, Roberts RJV, Schlegel P, Dhawan S, Tabano R, Dionne H, Christoforou C, Close K, Sutcliffe B, Giuliani B, Feng L, Costa M, Ihrke G, Meissner G, Bock D, Aso Y, Rubin G, Jefferis G. (2019) Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body eLife 10.7554/eLife.43079 | Link

Dolan M-J*, Belliart-Guérin G*, Bates AS, Frechter S, Lampin-Saint-Amaux A, Aso Y, Roberts RJV, Schegel P, Wong A, Hammad A, Bock D, Rubin G, Preat T, Plaçais P-Y, Jefferis G. (2018) Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila Neuron 10.1016/j.neuron.2018.08.037 | Link

Dolan M-J*, Luan H*, Shropshire W, Sutcliffe B, Cocanougher B, Scott R, Frechter S, Zlatic M, Jefferis G, White B. (2017) Facilitating Neuron-Specific Genetic Manipulations in Drosophila Using a Split GAL4 Repressor Genetics 10.1534/genetics.116.199687 | Link

Michael-John Dolan

Bio

I am a Life Sciences Research Foundation Postdoctoral Fellow at the Broad Institute of MIT and Harvard and Harvard Medical School, in the labs of Prof. Beth Stevens and Dr. Evan Macosko. My research focuses on building and applying novel molecular, viral, genomic and bioinformatic tools to understand microglia, the resident immune cells of the brain. I am particularly interested in how these cells coordinate brain plasticity and repair, with a current focus on remyelination.

Education

University of Cambridge, UK | 2017

Doctor of Philosophy in Neuroscience | Supervisor: Dr. Gregory Jefferis

Maynooth University, Ireland | 2011

Bachelor of Science in Biology and Applied Mathematics

Experience

Broad Institute of MIT and Harvard, USA | August 2018 - Present

Postdoctoral Fellow | Supervisors: Prof. Beth Stevens and Dr. Evan Macosko

Janelia Research Campus, USA | March 2017 - August 2018

Postdoctoral Fellow | Supervisors: Drs. Gerald Rubin and Gregory Jefferis

Selected Publications

A full bibliography can be found here. | ’*’ denotes joint first authorship.

Goeva A, Dolan M-J, Luu J, Garcia E, Boiarsky R, Gupta RM, Macosko E (2023) HiDDEN: A machine learning label refinement method for detection of disease-relevant populations in case-control single-cell transcriptomics Biorxiv (Submitted) https://doi.org/10.1101/2023.01.06.523013 | Link

Dolan M-J*, Therrien T*, Jereb S, Kamath T, Atkeson T, Marsh S, Goeva A, Lojek N, Murphy S, Joung J, Liu B, Limone F, Eggan K, Hacohen N, Bernstein B, Glass C, Leinonen V, Blurton-Jones M, Zhang F, Epstein C, Macosko E, Stevens B. (2022) A resource for generating and manipulating human microglial states in vitro Biorxiv (Accepted at Nature Immunology) https://doi.org/10.1101/2022.05.02.490100 | Link

^Article featured in Alzforum, an information nexus for neurodegeneration research | Link

Dolan M-J, Frechter S, Bates AS, Dan C, Huoviala P, Roberts RJV, Schlegel P, Dhawan S, Tabano R, Dionne H, Christoforou C, Close K, Sutcliffe B, Giuliani B, Feng L, Costa M, Ihrke G, Meissner G, Bock D, Aso Y, Rubin G, Jefferis G. (2019) Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body eLife 10.7554/eLife.43079 | Link

Dolan M-J*, Belliart-Guérin G*, Bates AS, Frechter S, Lampin-Saint-Amaux A, Aso Y, Roberts RJV, Schegel P, Wong A, Hammad A, Bock D, Rubin G, Preat T, Plaçais P-Y, Jefferis G. (2018) Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila Neuron 10.1016/j.neuron.2018.08.037 | Link

Dolan M-J*, Luan H*, Shropshire W, Sutcliffe B, Cocanougher B, Scott R, Frechter S, Zlatic M, Jefferis G, White B. (2017) Facilitating Neuron-Specific Genetic Manipulations in Drosophila Using a Split GAL4 Repressor Genetics 10.1534/genetics.116.199687 | Link